Stress-Induced Growth Arrest
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
CDKN1A (p21) enforces cell cycle arrest; ULBP2 is a stress-induced NKG2D ligand marking cellular stress; KDM6B is an epigenetic stress-response demethylase; ZC3H12A (MCPIP1) degrades inflammatory mRNAs under stress; PLK3 is activated by DNA damage/stress; PMEPA1 and KLF10 are TGF-β targets; NR4A3 is an activation/stress-induced nuclear receptor; TP53INP2 links to p53-mediated stress. Low expression (16% positive) consistent with a subpopulation under genotoxic or activation-induced stress with growth arrest.
Genes
CDKN1A, GNA15, KDM6B, KLF10, MMP9, MYADM, NOCT, NR4A3, PLK3, PMEPA1, RGCC, RNF19B, TP53INP2, TUBB2A, ULBP2, YPEL5, ZC3H12A
Most correlated modules
- NF-κB Activation · correlation 0.91
- BMP/TGF-β Inhibitory · correlation 0.87
- NF-κB Negative Feedback · correlation 0.86
- RNA Processing Stress · correlation 0.85
- Integrated Stress Response · correlation 0.84
- T cell Activation · correlation 0.82
- ER Stress UPR · correlation 0.80
- cAMP Immune Regulation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.