NF-κB Activation
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
All nine genes are core module members. REL (NF-κB subunit c-Rel), NFKBID (IκB-like NF-κB modulator), BIRC3 (IAP anti-apoptotic NF-κB target), KDM6B (H3K27me3 demethylase, NF-κB-regulated epigenetic activator), NR4A1 and NR4A3 (activation-induced nuclear receptors co-regulated with NF-κB), CD83 (NF-κB-driven activation marker), RASGEF1B (RasGEF downstream of TCR/NKR signaling), and ARL5B all converge on NF-κB-driven NK activation. Significantly upregulated in CD inflammation. This is a tight, coherent NF-κB activation module in NK cells.
Genes
ARL5B, BIRC3, CD83, KDM6B, NFKBID, NR4A1, NR4A3, RASGEF1B, REL
Most correlated modules
- TGF-beta Repression · correlation 0.93
- EGR2/3 NK Activation · correlation 0.92
- NK Activation Response · correlation 0.90
- NK Cell Activation · correlation 0.86
- NRF2 Stress Response · correlation 0.86
- Integrated Stress Response · correlation 0.84
- Transcription Elongation Control · correlation 0.84
- ER Stress Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.