NK Activation Response
Gene co-expression module in Natural Killer cells
| Category | activation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Top hub genes NR4A2, CREM, MAFF, and ZNF331 are all activation-induced transcription factors characteristic of NK/T cell activation responses. SRGN (serglycin) is a proteoglycan stored in NK cytotoxic granules. FTH1 reflects iron metabolism and oxidative stress adaptation. SELENOK is an ER selenoprotein involved in redox homeostasis. EIF1 supports translational activity. The module is enriched in remission (positive delta_remission) and slightly reduced with CD treatment, consistent with a homeostatic NK activation state. NR4A2/CREM/MAFF together define a cAMP/calcium-driven early activation transcriptional response in NK cells.
Genes
CREM, EIF1, FTH1, MAFF, NR4A2, SELENOK, SRGN, ZNF331
Most correlated modules
- TGF-beta Repression · correlation 0.92
- MAPK/AP-1 Signaling · correlation 0.91
- NF-κB Activation · correlation 0.90
- NRF2 Stress Response · correlation 0.89
- NK Cell Activation · correlation 0.89
- ER Stress Response · correlation 0.87
- Cytokine Feedback Response · correlation 0.85
- EGR2/3 NK Activation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.