ER Stress Response
Gene co-expression module in Natural Killer cells
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes: HERPUD1 (ER stress/UPR, ERAD component), DNAJB6 (HSP40 co-chaperone, protein folding), GADD45B (stress-responsive, DNA damage/growth arrest), CYCS (cytochrome c, apoptosis signal), EIF4A3 (eIF4A RNA helicase, translation initiation), EIF5 (translation initiation factor), SERTAD1 (cell cycle/CDK4 activator), SAP18 (Sin3A-associated, transcriptional repression). The module combines ER stress/UPR (HERPUD1, DNAJB6), stress-responsive growth arrest (GADD45B), apoptotic signaling (CYCS), and translation initiation (EIF4A3, EIF5). The dominant theme is cellular stress response with UPR/proteotoxic stress flavor. Neighbor M14 is a strong heat shock/chaperone module and M50 is also heat shock — this neighborhood strongly supports a proteotoxic/ER stress program. CYCS adds an apoptotic dimension consistent with severe ER stress.
Genes
ARF4, CYCS, DNAJB6, EIF4A3, EIF5, GADD45B, HERPUD1, SAP18, SERTAD1
Most correlated modules
- Transcription Elongation Control · correlation 0.88
- NK Activation Response · correlation 0.87
- TGF-beta Repression · correlation 0.85
- Cytokine Feedback Response · correlation 0.84
- Heat Shock Response · correlation 0.84
- NF-κB Activation · correlation 0.82
- EGR2/3 NK Activation · correlation 0.82
- NRF2 Stress Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.