NK Inflammatory Activation
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
LPIN2 encodes a phosphatidic acid phosphatase involved in lipid metabolism and inflammatory signaling (mutations cause Majeed syndrome). STIP1 is a stress-inducible co-chaperone (HSP70/HSP90 organizer). FGFR1OP2 is involved in cytoskeletal organization. FCER1G encodes the Fc receptor gamma chain, critical for NK cell activating receptor signaling (CD16, NKG2D complexes). ITM2B is involved in amyloid processing. PTGES3 is a cytosolic prostaglandin E synthase linking to inflammatory lipid mediator production. CCT4 is a chaperonin subunit. BST2 (tetherin) is an interferon-stimulated gene with antiviral and NK cell regulatory roles. LPXN (leupaxin) is a focal adhesion protein expressed in hematopoietic cells. MBNL1 is an RNA-binding protein. The significant upregulation in CD inflammation (delta_inflammation_CD = 1.287 sig.) and downregulation with treatment suggests an inflammatory activation program. FCER1G and BST2 are particularly relevant to NK cell activation and interferon responses. The module likely reflects NK cell inflammatory activation in CD.
Genes
BST2, CCT4, FCER1G, FGFR1OP2, ITM2B, LPIN2, LPXN, MBNL1, PTGES3, STIP1
Most correlated modules
- Mature NK Identity · correlation 0.82
- NK Cytoskeletal Activation · correlation 0.79
- Cellular Homeostasis · correlation 0.78
- NK Homeostatic Survival · correlation 0.76
- ILC1/NK Cytotoxic · correlation 0.74
- NK Cell Activation · correlation 0.73
- NK Immune Checkpoint · correlation 0.71
- Actin Cytoskeleton Remodeling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.