Actin Cytoskeleton Remodeling
Gene co-expression module in Natural Killer cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
ARPC5 and ARPC3 are subunits of the Arp2/3 complex, which nucleates branched actin filaments. MYL6 and MYL12B are myosin light chains involved in actomyosin contractility. ABRACL is an actin-binding regulator of the Arp2/3 complex. YWHAB (14-3-3β) regulates cytoskeletal signaling. S100A11 is a calcium-binding protein involved in actin dynamics and membrane repair. PRDX2 is a peroxiredoxin with roles in cytoskeletal regulation. ATP5F1D (ATP synthase) and DRAP1 (transcription co-repressor) and XRCC5 (Ku80, DNA repair) are peripheral members. The Arp2/3 complex + myosin light chains + ABRACL form a coherent actin cytoskeleton remodeling program. Neighbor M7 also contains ACTR2/3 (Arp2/3 ATPases), reinforcing this actin theme.
Genes
ABRACL, ARPC3, ARPC5, ATP5F1D, DRAP1, MYL12B, MYL6, PRDX2, S100A11, XRCC5, YWHAB
Most correlated modules
- Oxidative Stress Response · correlation 0.87
- Cellular Homeostasis · correlation 0.85
- NK Cell Activation · correlation 0.83
- Immunoproteasome Activation · correlation 0.81
- Glycolytic Metabolism · correlation 0.79
- NK Cytotoxic Activation · correlation 0.77
- hnRNP RNA Processing · correlation 0.77
- NK Cytotoxic Signaling · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.