NK Cytoskeletal Activation
Gene co-expression module in Natural Killer cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
CAPG (macrophage capping protein, actin dynamics), SRGAP3 (Rho GTPase-activating protein, cytoskeletal regulation), COTL1 (actin-binding, coactosin-like), EVL (Ena/VASP family, actin polymerization), and CLNK (cytoplasmic linker kinase expressed in NK/mast cells) collectively point to actin cytoskeletal remodeling. TNFRSF18 (GITR) marks activated NK cells. ITM2A is an early NK/T activation marker. PGK1 (glycolysis) may reflect metabolic support for cytoskeletal activity. PEBP1 modulates MAPK/Raf signaling. This module likely represents NK cell cytoskeletal reorganization associated with activation or migration, consistent with the inflamed intestinal context.
Genes
CAPG, CLNK, COTL1, EVL, GPR82, ITM2A, PEBP1, PGK1, PLEKHO1, SRGAP3, TMEM14C, TNFRSF18
Most correlated modules
- NK Tissue Residency · correlation 0.91
- Resident NK program · correlation 0.88
- Hypoxia Response · correlation 0.81
- NK Checkpoint Receptors · correlation 0.80
- NK Inflammatory Activation · correlation 0.79
- Mature NK Identity · correlation 0.78
- Tissue-Resident NK · correlation 0.75
- Resident NK cells · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.