PTGES3 — Prostaglandin E synthase 3
PTGES3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTGES3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | mRNA Splicing RNA processing & translation | DIAPH1, EIF4A3, FUBP1, GLRX5, HNRNPA2B1, HNRNPA3, HNRNPD, KHDRBS1 +8 more | View in SCUBA |
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ANXA5, ARF1, ATP6AP2, MORF4L1, MTDH, OCIAD1, RAB2A, SELENOF +6 more | View in SCUBA |
| Gamma-delta T cells | Heat Shock Response Stress | AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4 +13 more | |
| Goblet cells | CCT Chaperonin Complex Protein processing & ER | CCT5, CCT6A, HDGF, HNRNPA3, HNRNPC, IDH2, SMS, SRP9 +2 more | View in SCUBA |
| Innate lymphoid cells | TRiC Chaperonin Folding Protein processing & ER | ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC +9 more | View in SCUBA |
| Macrophages | RNA Processing & Repair Housekeeping | BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4 +31 more | View in SCUBA |
| Natural Killer cells | NK Inflammatory Activation Inflammation | BST2, CCT4, FCER1G, FGFR1OP2, ITM2B, LPIN2, LPXN, MBNL1 +1 more | View in SCUBA |
About the gene
| Synonyms | cPGES, p23, TEBP |
|---|---|
| Chromosome | 12: 56663341-56688408 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone, Isomerase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism |
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.