LPIN2 — Lipin 2
LPIN2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LPIN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Transcriptional regulation DNA/chromatin regulation | CCNH, CWC25, DYNLL2, EIF2A, GOLGB1, IVNS1ABP, JMJD1C, KRR1 +8 more | View in SCUBA |
| Endothelial | Inflammatory EC Activation Inflammation | ANGPT2, B3GNT5, BAIAP2, EPHA2, GMFB, HIC1, HMOX1, JUP +6 more | View in SCUBA |
| Enterocytes | Stress-responsive transcription Stress | AAK1, ABTB2, PLEC, RIGI, SKIL, TMCC3 | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more | |
| Innate lymphoid cells | IFN-gamma Response Inflammation | APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 more | View in SCUBA |
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L +19 more | View in SCUBA |
| Natural Killer cells | NK Inflammatory Activation Inflammation | BST2, CCT4, FCER1G, FGFR1OP2, ITM2B, LPXN, MBNL1, PTGES3 +1 more | View in SCUBA |
About the gene
| Synonyms | KIAA0249 |
|---|---|
| Chromosome | 18: 2885296-3013144 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Fatty acid metabolism, Lipid metabolism, Transcription, Transcription regulation |
Function
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.