Circadian NF-κB Crosstalk
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
PER1 is a core circadian clock gene (Period 1) and the top hub. IRF2BP2 is a transcriptional repressor of NF-κB and inflammatory genes. MAP3K8 (TPL2/COT1) is a key inflammatory kinase activating ERK and NF-κB downstream of TLR/TNF signals. RELB is an NF-κB family member. SLC7A5 (LAT1) is an amino acid transporter that activates mTORC1 and supports effector NK cell metabolism. DUSP8 is a MAPK phosphatase providing negative feedback. ISCA1 is involved in iron-sulfur cluster assembly. The combination of PER1 with inflammatory kinases (MAP3K8, RELB) and the significant upregulation in IBD inflammation suggests this module captures circadian clock-NF-κB crosstalk in activated NK cells, consistent with neighbor modules M43 (CRY1) and M52 (NR1D2).
Genes
DUSP8, IRF2BP2, ISCA1, MAP3K8, MED10, PER1, RELB, RHOH, SLC7A5
Most correlated modules
- NF-κB Activation · correlation 0.79
- Glucocorticoid Response · correlation 0.75
- TGF-β Antagonism · correlation 0.69
- TGF-beta Response · correlation 0.68
- Autophagy-Inflammation Stress · correlation 0.63
- NK/ILC Differentiation · correlation 0.49
- NK Cell Exhaustion · correlation 0.49
- Circadian Innate Signaling · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.