N4BP3 — NEDD4 binding protein 3
N4BP3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
N4BP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenesis ECM remodeling | ADM, APOD, CHST15, CMTM3, GPIHBP1, GRAP, HOMER3, LOX +7 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more | |
| Mucosal-associated invariant T cell | BMP/TGF-β Inhibitory Immune regulation | ACHE, BUD31, FAM43A, ID1, LMNA, PRR7, RGS16, SMAD7 +2 more | |
| Natural Killer cells | TGF-beta Response Immune regulation | ANKRD9, AUTS2, CDK17, GNA13, MTFP1, RAB5IF, RBM38, TAMALIN +2 more | View in SCUBA |
About the gene
| Synonyms | LZTS4 |
|---|---|
| Chromosome | 5: 178113532-178126081 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Immunity, Innate immunity, Neurogenesis |
Function
Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2. Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.