NK Cell Identity
Gene co-expression module in Natural Killer cells
| Category | Differentiation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include FCMR (IgM Fc receptor expressed on NK cells), ETS1 (master transcription factor for NK/lymphocyte development), PIK3R5 (PI3K signaling in NK activation), and ICAM2 (adhesion molecule on NK cells). FKBP11 is involved in ER protein processing. The module is upregulated in CD inflammation and shows uniform expression across NK subsets, consistent with a broadly expressed NK cell identity program driven by ETS1-dependent transcription.
Genes
APBA2, APMAP, COLQ, ETS1, FCMR, FKBP11, GSAP, ICAM2, MRPL10, PIK3R5, YPEL3
Most correlated modules
- NK Degranulation Activation · correlation 0.62
- NK Activation Signaling · correlation 0.58
- Inflammatory Stress Response · correlation 0.55
- Interferon NK Activation · correlation 0.54
- Cytotoxic NK Maturation · correlation 0.53
- Innate Sensing NK Regulation · correlation 0.49
- NK TGF-β Regulation · correlation 0.44
- Cytoskeletal Remodeling · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.