RAB5IF — RAB5 interacting factor
RAB5IF belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB5IF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB regulation TCR/AP1/NFKb pathway | ARIH2, CD58, CYLD, DAD1, DERL1, EED, ELOVL5, NFAT5 +9 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10 +13 more | |
| Macrophages | Glycolytic Redox Metabolism Lipid metabolism | AGPAT2, ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC +18 more | View in SCUBA |
| Monocytes | Pentose Phosphate Pathway Innate immunity | ACAP1, AP5B1, CCDC69, CCND3, CITED4, CORO2A, DYSF, EIF4E3 +4 more | View in SCUBA |
| Natural Killer cells | TGF-beta Response Immune regulation | ANKRD9, AUTS2, CDK17, GNA13, MTFP1, N4BP3, RBM38, TAMALIN +2 more | View in SCUBA |
About the gene
| Synonyms | C20orf24, PNAS-11, RCAF1, RIP5 |
|---|---|
| Chromosome | 20: 36605779-36612557 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Predicted membrane proteins |
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane. In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.