MYL6 — Myosin light chain 6

MYL6 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MYL6's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	ACTB, ACTG1, ACTR3, ARPC1B, ARPC2, ARPC4, ARPC5, BRK1 +14 more	View in SCUBA
CD4⁺ T cells	Cytoskeleton & metabolism Cytoskeletal	ATP5F1D, ATP5MC3, ATP6V0E1, BRK1, CAP1, LCK, NEDD8, PPP1R18 +11 more	View in SCUBA
CD8⁺ T cells	ER-Golgi Trafficking Protein processing & ER	BLOC1S1, CLIC1, COPE, COPZ1, FIBP, IFI27L2, RAP1B, SURF4 +1 more	View in SCUBA
Enterocytes	Abundant Transcript Baseline Housekeeping	ATP5IF1, C15orf48, CALM2, CHCHD2, CSTB, GHITM, KRT8, LGALS3 +6 more	View in SCUBA
Fibroblasts	Focal Adhesion ECM Migration & adhesion	ACTN1, CLIC4, COL4A1, COL4A2, MPRIP, MRPL33, NDUFA4, PARVA +6 more	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Actin cytotoxicity	ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI +14 more
Glial cells	ER Translocon Activity Protein processing & ER	ARPC2, CALR, EDF1, MRPL52, NDUFA1, OST4, PFN1, PPIB +3 more	View in SCUBA
Goblet cells	S100 Calcium Signaling Stress	CIB1, CLDN7, CLTB, GUK1, MYL12B, RHOC, S100A11, S100A13 +4 more	View in SCUBA
Innate lymphoid cells	Actin Cytoskeleton Remodeling Cytoskeleton & motility	APRT, ARPC2, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2 +17 more	View in SCUBA
Lymphatic endothelial	Actomyosin Cytoskeleton Cytoskeletal	BRI3, CD63, CFL1, CHCHD2, COX4I1, EDF1, GABARAPL2, HINT1 +8 more	View in SCUBA
Macrophages	Proteasome UPS Housekeeping	ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more	View in SCUBA
Mucosal-associated invariant T cell	ER Glycosylation & Ubiquitin Protein processing & ER	AIP, ALDOA, ATP5MG, COX6A1, COX6B1, ELOB, FIS1, GAPDH +9 more
Natural Killer cells	Actin Cytoskeleton Remodeling Cytoskeleton & motility	ABRACL, ARPC3, ARPC5, ATP5F1D, DRAP1, MYL12B, PRDX2, S100A11 +2 more	View in SCUBA
Neutrophils	Actin Cytoskeleton Dynamics Cytoskeletal	ACTB, ACTG1, ARPC5, CFL1, CORO1A, ITGB2, PFN1, RGL4 +6 more
Pericytes	Focal Adhesion Cytoskeleton Cytoskeletal	ARPC5, CAVIN3, CNN3, MAP1B, PDLIM2, TGFB1I1, TLN1, TPM4	View in SCUBA
Smooth muscle cells	SMC contractile apparatus Contractility	ACTA2, ACTB, CALD1, CAV1, DSTN, MYL9, PPP1R14A, SH3BGRL +2 more	View in SCUBA

About the gene

Synonyms	ESMLC, MLC1SM, MLC3NM
Chromosome	12: 56158346-56163496
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Motor protein, Muscle protein, Myosin

Function

Regulatory light chain of myosin. Does not bind calcium

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.