SCUBA

MYL12B — Myosin light chain 12B

MYL12B belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MYL12B's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsActin Cytoskeleton
Cytoskeletal
COTL1, GNAI2, HIGD2A, MOB1A, MPG, MYL12A, NDUFB5, PRR13 +8 moreView in SCUBA
CD4⁺ T cellsActin Cytoskeleton
Cytoskeletal
ABRACL, CAPZB, CD53, CFL1, CKLF, DRAP1, GUK1, PPIB +6 moreView in SCUBA
EndothelialMitochondrial OxPhos
Mitochondrial & OxPhos
ARPC3, CLTB, COX6A1, COX7A2, COX7B, DAD1, ELOB, NDUFA11 +9 moreView in SCUBA
EnterocytesActin cytoskeleton
Cytoskeletal
ACTB, ACTG1, CAST, CDC42EP5, CLDN7, JPT1, PIGR, TMEM54View in SCUBA
FibroblastsER Secretory Processing
Housekeeping
DAD1, ELOB, FKBP1A, POLR2L, PPIB, RABAC1, SPCS1, SSR4 +2 moreView in SCUBA
Gamma-delta T cellsCytotoxic Effector Actin
cytotoxicity
ARPC2, ARPC5, ATOX1, BRK1, CFL1, CLIC1, CORO1A, DBI +14 more
Glial cellsProteasomal Proteostasis
Protein processing & ER
CD63, CLIC1, COX7A2, ELOB, PDIA6, PSMA7, PSMB1, PSMB3 +3 moreView in SCUBA
Goblet cellsS100 Calcium Signaling
Stress
CIB1, CLDN7, CLTB, GUK1, MYL6, RHOC, S100A11, S100A13 +4 moreView in SCUBA
Innate lymphoid cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
APRT, ARPC2, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2 +17 moreView in SCUBA
Lymphatic endothelialActomyosin Cytoskeleton
Cytoskeletal
BRI3, CD63, CFL1, CHCHD2, COX4I1, EDF1, GABARAPL2, HINT1 +8 moreView in SCUBA
MacrophagesProteasome UPS
Housekeeping
ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 moreView in SCUBA
Mucosal-associated invariant T cellCyclophilin-Mediated Folding
Housekeeping
B2M, BBLN, BCL7C, C12orf75, CFL1, EDF1, EIF3L, ERH +10 more
Natural Killer cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
ABRACL, ARPC3, ARPC5, ATP5F1D, DRAP1, MYL6, PRDX2, S100A11 +2 moreView in SCUBA
Smooth muscle cellsNon-muscle Actomyosin
Cytoskeletal
C1R, CAST, CD63, CLIC1, DYNLL1, FILIP1L, LDHA, LIMS1 +4 moreView in SCUBA

About the gene

SynonymsMRLC2
Chromosome18: 3261479-3278461
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Molecular functionMotor protein, Muscle protein, Myosin

Function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.