NK Cytotoxic Signaling
Gene co-expression module in Natural Killer cells
| Category | Cytotoxicity |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub genes HCST (DAP10, signaling adaptor for NKG2D), TYROBP (DAP12, signaling adaptor for multiple NK receptors), B2M (MHC-I component, NK licensing), CD48 (ligand for 2B4/CD244 NK receptor), TMSB10 (actin sequestering, cytoskeletal), CALM1 (calmodulin, calcium signaling), APOBEC3G (innate immune defense), MYL12A (myosin light chain, cytoskeletal/cytotoxic), and TRGC1 (gamma-delta T cell receptor constant region - possible minor contamination or ILC). HCST and TYROBP are canonical NK cell signaling adaptors central to cytotoxic activation. B2M and CD48 support NK licensing and target recognition. CALM1 and MYL12A support cytotoxic granule release machinery. GLIPR2 has roles in immune regulation. This module represents core NK cell identity and cytotoxic signaling machinery. The mild CD inflammation association is consistent with NK activation in IBD.
Genes
APOBEC3G, B2M, CALM1, CD48, GLIPR2, HCST, MYL12A, TMSB10, TRGC1, TYROBP
Most correlated modules
- Cellular Homeostasis · correlation 0.80
- Cytokine Feedback Response · correlation 0.78
- Mature NK Identity · correlation 0.77
- mRNA Splicing · correlation 0.75
- Actin Cytoskeleton Remodeling · correlation 0.75
- IFN-stimulated NK · correlation 0.68
- NK Cell Activation · correlation 0.62
- NK Cytotoxic Activation · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.