SEC11A — SEC11 homolog A, signal peptidase complex subunit
SEC11A belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEC11A's module in each cell type
About the gene
| Synonyms | SEC11L1, sid2895, SPC18, SPCS4A |
|---|---|
| Chromosome | 15: 84669538-84716460 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protease |
Function
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N- terminal signal peptides that contain a hydrophobic alpha-helix (h- region) shorter than 18-20 amino acids
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.