Energy Metabolism
Gene co-expression module in Natural Killer cells
| Category | Metabolism |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
PGAM1 (phosphoglycerate mutase, glycolysis) and PKM (pyruvate kinase, glycolysis) are glycolytic enzymes. ATP5MC2 (ATP synthase subunit c, Complex V), NDUFA11 and NDUFB9 (NADH dehydrogenase Complex I subunits) represent oxidative phosphorylation. TRAPPC1 (TRAPP complex, vesicle trafficking), BLOC1S1 (biogenesis of lysosome-related organelles complex), ARL6IP4 (splicing factor/ER). The co-expression of glycolytic and OxPhos genes suggests a general cellular energy metabolism module, possibly reflecting metabolic flexibility or a housekeeping energy program. Upregulated in CD inflammation.
Genes
ARL6IP4, ATP5MC2, BLOC1S1, NDUFA11, NDUFB9, PGAM1, PKM, TRAPPC1
Most correlated modules
- Glycolytic Metabolism · correlation 0.83
- Immunoproteasome Activation · correlation 0.78
- Actin Cytoskeleton Remodeling · correlation 0.77
- Chromatin Remodeling · correlation 0.72
- Actin Cytoskeleton Remodeling · correlation 0.69
- Oxidative Stress Response · correlation 0.65
- G2/M Transition · correlation 0.63
- NK Cell Activation · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.