SCUBA

NDUFA11 — NADH:ubiquinone oxidoreductase subunit A11

NDUFA11 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFA11's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ATP5F1D, ATP5ME, COX6A1, COX6B1, COX6C, DNAJC8, NDUFA4, NEDD8 +6 moreView in SCUBA
CD4⁺ T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ANP32A, ATP5F1A, ATP5F1B, COX7A2, COX7B, GADD45GIP1, GNG5, MRPL21 +10 moreView in SCUBA
CD8⁺ T cellsMitochondrial ETC/OxPhos
Mitochondrial & OxPhos
AP2S1, BAX, COX6A1, ERH, HSD17B10, LSM2, MAD2L2, MEA1 +7 moreView in SCUBA
EndothelialMitochondrial OxPhos
Mitochondrial & OxPhos
ARPC3, CLTB, COX6A1, COX7A2, COX7B, DAD1, ELOB, MYL12B +9 moreView in SCUBA
FibroblastsCullin-RING Ubiquitin Ligase
Housekeeping
ARPC3, LAMTOR5, MRPL51, NDUFB11, NDUFC2, OST4, RBX1, RNF7 +3 moreView in SCUBA
Gamma-delta T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ARPC1B, ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, CSNK2B +12 more
Glial cellsOxidative Stress Response
Stress
CAP1, CD59, CXXC5, EEF2, ENO1, HNRNPF, KLF9, NFE2L2 +3 moreView in SCUBA
Innate lymphoid cellsMitochondrial OxPhos
Mitochondrial & OxPhos
AKR7A2, ANXA6, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, ATP5PB, BSG +21 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
ARL2, BLOC1S1, CHMP2A, CHURC1, COX5B, DCTN3, FIS1, MRPL43 +5 moreView in SCUBA
MacrophagesProtein Homeostasis Mixed
Housekeeping
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 moreView in SCUBA
Mucosal-associated invariant T cellNADPH Oxidase & Innate Immune
Inflammation
ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GABARAP, GNG5, HIGD2A +9 more
Natural Killer cellsEnergy Metabolism
Metabolism
ARL6IP4, ATP5MC2, BLOC1S1, NDUFB9, PGAM1, PKM, TRAPPC1View in SCUBA
Smooth muscle cellsOxPhos & proteasome
Mitochondrial & OxPhos
CD151, CHCHD2, COX5B, EID1, NDUFB2, NDUFB9, NEDD8, PARK7 +8 moreView in SCUBA

About the gene

SynonymsB14.7
Chromosome19: 5891276-5904006
Predicted locationIntracellular, Membrane
Essential geneYes
Protein classDisease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.