SCUBA

PGAM1 — Phosphoglycerate mutase 1

PGAM1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PGAM1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS +19 moreView in SCUBA
CD8⁺ T cellsGlycolysis Program
Housekeeping
ADRM1, CSNK2B, ENO1, MTHFD2, NUTF2, P4HB, PKM, POLR2E +6 moreView in SCUBA
EndothelialGlycolysis Activation
Housekeeping
ATP5F1B, BSG, CCT7, COPE, FKBP3, GAPDH, ISOC2, KDELR2 +8 moreView in SCUBA
FibroblastsER-Golgi Trafficking
Vesicular traficking
ARL1, CALR, COPE, DNAJC3, EMC7, GDI2, MPG, MYDGF +6 moreView in SCUBA
Goblet cellsProteostasis Housekeeping
Housekeeping
ADRM1, EIF2S2, GNB2, MAGOHB, NME1, NUDC, OAZ1, PARK7 +4 moreView in SCUBA
Innate lymphoid cellsGlycolysis & OxPhos
Metabolism
ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1 +10 moreView in SCUBA
Lymphatic endothelialGlycolytic Housekeeping
Housekeeping
CALCOCO2, CANX, CAP1, DPYSL2, DYNC1I2, EIF2S2, ENO1, GIMAP8 +1 moreView in SCUBA
MacrophagesGlycolytic Metabolism
Housekeeping
ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5 +30 moreView in SCUBA
Natural Killer cellsEnergy Metabolism
Metabolism
ARL6IP4, ATP5MC2, BLOC1S1, NDUFA11, NDUFB9, PKM, TRAPPC1View in SCUBA
Smooth muscle cellsMitochondrial Housekeeping
Housekeeping
APP, COX7A2L, EIF5B, GABARAPL2, LAMTOR4, NDUFAB1, SPCS2, TMEM14C +2 moreView in SCUBA

About the gene

SynonymsPGAM-B, PGAMA
Chromosome10: 97426191-97433444
Predicted locationIntracellular
Essential geneYes
Protein classCandidate cardiovascular disease genes, Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionHydrolase, Isomerase
Biological processGlycolysis

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglyceratea crucial step in glycolysis, by using 2,3- bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho- glyceroyl phosphate

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.