LYAR — Ly1 antibody reactive
LYAR belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LYAR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, PLP2 +11 more | View in SCUBA |
| CD8⁺ T cells | Effector Memory CD8 T cell maturation | CLDND1, DENND2D, GIMAP1, GIMAP4, GIMAP7, GPR183, GZMK, ITM2C +3 more | View in SCUBA |
| Endothelial | ER Calcium Stress Stress | ACOT7, ATP2A2, CALU, ELOVL5, GTF2A2, PSMD7, RCC2, UFD1 +1 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more | |
| Macrophages | Mitochondrial Housekeeping Mitochondrial & OxPhos | BLOC1S2, BUD31, C14orf119, CCT5, CDC26, DGUOK, EIF2S1, GADD45GIP1 +11 more | View in SCUBA |
| Natural Killer cells | NK Activation Signaling activation | C12orf75, F2R, GRAP2, GZMH, LIME1, RGS9, SSBP3, SYT11 +1 more | View in SCUBA |
About the gene
| Synonyms | ZC2HC2, ZLYAR |
|---|---|
| Chromosome | 4: 4267701-4290154 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Immunity, Innate immunity, rRNA processing, Transcription, Transcription regulation |
Function
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.