LIME1 — Lck interacting transmembrane adaptor 1
LIME1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIME1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Effector IFN Response cytotoxicity | AGTRAP, ANXA1, B2M, CYBA, EMP3, FXYD5, GZMM, IFITM1 +9 more | |
| Mucosal-associated invariant T cell | T cell Surface Signaling TCR Signaling | CD37, ICAM3, MFNG, MZT2A, NAA10, PLSCR3, SIGIRR | |
| Natural Killer cells | NK Activation Signaling activation | C12orf75, F2R, GRAP2, GZMH, LYAR, RGS9, SSBP3, SYT11 +1 more | View in SCUBA |
About the gene
| Synonyms | dJ583P15.4, FLJ20406, LIME |
|---|---|
| Chromosome | 20: 63736283-63739103 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4- mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.