S/G2M Cell Cycle
Gene co-expression module in Natural Killer cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
CKS2 is a CDK regulatory subunit essential for cell cycle progression (G2/M); NASP is a histone chaperone active in S-phase; KPNA2 (importin alpha 1) is required for nuclear import of cell cycle regulators and is overexpressed in proliferating cells; JPT1 (HN1) is associated with cell cycle and proliferation; NAP1L1 is a nucleosome assembly protein active during DNA replication (S-phase); TUBA1C is an alpha-tubulin expressed during mitosis; CALM2 (calmodulin) regulates CDK activity; CDK2AP2 modulates CDK2. PRDX1 is a redox enzyme also involved in cell cycle checkpoint. Together these genes strongly indicate S/G2/M phase cell cycle progression in a subset of NK cells.
Genes
CALM2, CDK2AP2, CKS2, JPT1, KPNA2, NAP1L1, NASP, PRDX1, TUBA1C
Most correlated modules
- Metabolic Activation · correlation 0.85
- hnRNP RNA Processing · correlation 0.84
- Transcription Elongation Control · correlation 0.77
- TGF-beta Repression · correlation 0.76
- mRNA Splicing · correlation 0.76
- NF-κB Activation · correlation 0.74
- NK Cell Activation · correlation 0.73
- Cytokine Feedback Response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.