IFN-stimulated NK
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include UTRN (utrophin, cytoskeletal/membrane scaffold), RNF213 (E3 ubiquitin ligase with antiviral/IFN-stimulated roles), PTPRC (CD45, pan-leukocyte phosphatase), ATM (DNA damage response kinase), MBP (myelin basic protein - possible contamination or non-canonical expression), ITGAL (LFA-1/CD11a, adhesion/homing), APOL6 (IFN-stimulated, antiviral), CTSC (cathepsin C, granule protease activation), RORA (nuclear receptor, circadian/immune regulation), PILRB (activating receptor), AKNA (transcription factor, immune cell differentiation), and MXD1 (transcriptional repressor). The strong upregulation in both UC and CD inflammation and decrease in remission is notable. CTSC activates granzymes and perforin in NK cells. ITGAL supports tissue homing. APOL6 and RNF213 are IFN-stimulated genes. ATM links to DNA damage/stress responses. This module appears to represent an interferon-stimulated, inflammation-associated NK program with cytotoxic and adhesion components. MBP is anomalous but may reflect low-level ambient RNA.
Genes
AKNA, APOL6, ATM, CTSC, ITGAL, MBP, MXD1, PILRB, PTPRC, RNF213, RORA, SACM1L, UTRN
Most correlated modules
- Mature NK Identity · correlation 0.68
- NK Cytotoxic Signaling · correlation 0.68
- NK Homeostatic Survival · correlation 0.65
- Innate Sensing NK Regulation · correlation 0.64
- NK Cell Activation · correlation 0.64
- NK Cytotoxic Activation · correlation 0.64
- NK Cell Maturation · correlation 0.52
- NK Lymphocyte Survival · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.