Autophagy-Inflammation Stress
Gene co-expression module in Natural Killer cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
SQSTM1 (p62) and MAP1LC3B are canonical autophagy markers. DDIT3 (CHOP) is the integrated stress response/ER stress transcription factor. ZC3H12A (Regnase-1/MCPIP1) is an endonuclease that degrades inflammatory mRNAs, acting as a post-transcriptional brake on inflammation. ICAM1 is an NF-κB-driven adhesion molecule upregulated in inflammation. BCL2A1 is an anti-apoptotic NF-κB target. KLF10 is a TGF-β-induced repressor. STX11 is a SNARE protein required for NK degranulation. MKNK2 (MNK2) phosphorylates eIF4E under stress. The module combines autophagy, ER/integrated stress, and inflammatory NF-κB signaling — strongly upregulated in CD inflammation. The co-expression of autophagy and stress genes with inflammatory targets suggests a stress-coupled inflammatory response.
Genes
BCL2A1, DDIT3, ICAM1, IFFO2, JMJD6, KLF10, MAP1LC3B, MKNK2, SIK3, SQSTM1, STX11, ZC3H12A
Most correlated modules
- NF-κB Activation · correlation 0.88
- Integrated Stress Response · correlation 0.85
- TGF-β Antagonism · correlation 0.79
- NF-κB Activation · correlation 0.78
- TGF-beta Repression · correlation 0.77
- EGR2/3 NK Activation · correlation 0.74
- NK Activation Response · correlation 0.73
- AP-1 Immediate Early · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.