SLC7A5 — Solute carrier family 7 member 5
SLC7A5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC7A5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1 +6 more | View in SCUBA |
| CD8⁺ T cells | Proliferating CD8 T cell Cell cycle | AHI1, ARL3, CDK6, GOLIM4, SQLE, TNIP3, TNS3, VCAM1 | View in SCUBA |
| Gamma-delta T cells | NF-κB Activation Inflammation | DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1 +13 more | |
| Macrophages | Integrated Stress Response Stress | AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD +17 more | View in SCUBA |
| Monocytes | Hypoxia Response Tissue adaptation | ANPEP, ELL2, GNA15, HIF1A, NDRG1, RUNX1, SDC4, SPAG9 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Activation Inflammation | DUSP5, DUSP8, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1 +8 more | |
| Natural Killer cells | Circadian NF-κB Crosstalk Inflammation | DUSP8, IRF2BP2, ISCA1, MAP3K8, MED10, PER1, RELB, RHOH | View in SCUBA |
About the gene
| Synonyms | CD98, D16S469E, E16, LAT1, MPE16 |
|---|---|
| Chromosome | 16: 87830023-87869507 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Amino-acid transport, Transport |
Function
The heterodimer with SLC3A2 functions as a sodium- independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine. The heterodimer with SLC3A2 mediates the uptake of L-DOPA (By similarity). Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L- homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane. (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.