RHOH — Ras homolog family member H
RHOH belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHOH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B Cell Identity Signaling B cell maturation | ARID4B, ELF1, LYN, PAX5, ST8SIA4, TMEM131, UGCG | View in SCUBA |
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, HBP1, KDM2A, NCOA3 +10 more | View in SCUBA |
| Gamma-delta T cells | Autophagy Stress Response Stress | AKIRIN1, BRD9, CDKN2AIP, DHX36, DNAJB2, FOXO3, MLXIP, ODF2L +11 more | |
| Monocytes | NF-κB Counter-regulation Inflammatory | ABL2, C15orf48, CD274, GPR84, IL1RN, TNFAIP8, TNIP3 | View in SCUBA |
| Natural Killer cells | Circadian NF-κB Crosstalk Inflammation | DUSP8, IRF2BP2, ISCA1, MAP3K8, MED10, PER1, RELB, SLC7A5 | View in SCUBA |
About the gene
| Synonyms | ARHH, TTF |
|---|---|
| Chromosome | 4: 40191011-40246967 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase- activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.