SCUBA

TPT1 — Tumor protein, translationally-controlled 1

TPT1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TPT1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsRibosomal proteins
Housekeeping
CD48, ESD, PARP11, RPLP0, RPLP1, RPS19, VEGFBView in SCUBA
CD8⁺ T cellsNaive/Memory CD8
T cell maturation
C1orf162, CD48, CD55, EEF1B2, GPR155, IL7R, MATK, MYBL1 +3 moreView in SCUBA
EndothelialInflammatory Angiogenesis
Endothelial cell development
FAM241A, FAM43A, KLF6, MYC, NFATC1, PHLDA1, PIM3, PLEKHO2 +7 moreView in SCUBA
Gamma-delta T cellsTranslation & Proteostasis
RNA processing & translation
ARAP2, ATG13, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2 +15 more
Glial cellsRNA Translation Processing
RNA processing & translation
CYCS, EEF1B2, EEF1D, HNRNPA1, HNRNPH3, LDHA, NAP1L1, NPM1 +5 moreView in SCUBA
Goblet cellsEpithelial Membrane Identity
Epithelial development
EIF3H, EPCAM, ITM2B, PDLIM1, RAC1, SLC25A3, TMEM176A, TMEM176B +1 moreView in SCUBA
Innate lymphoid cellsMitochondrial Housekeeping
Mitochondrial & OxPhos
COX7A2, COX7B, EEF1B2, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1 +8 moreView in SCUBA
MacrophagesMHC-II Antigen Presentation
Innate immunity
AIF1, B2M, C1QA, C1QB, C1QC, CD68, CD74, CST3 +19 moreView in SCUBA
Natural Killer cellsCytokine Feedback Response
Immune regulation
DYNLL1, LMO4, N4BP2L2, PABPC1, PAXX, PRPF4B, SOCS3, VMP1View in SCUBA
NeutrophilsGlycolytic Metabolism
Housekeeping
CSTB, CTSD, ENO1, FAM210A, GAPDH, GRN, GSTO1, LDHA +4 more
Smooth muscle cellsTranslation elongation housekeeping
Housekeeping
COX4I1, EEF1A1, EEF1D, EEF2, FTH1, FTL, GAPDH, PTMA +4 moreView in SCUBA

About the gene

Synonymsfortilin, TCTP
Chromosome13: 45333471-45341284
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins

Function

Involved in calcium binding and microtubule stabilization. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.