PAXX — PAXX non-homologous end joining factor
PAXX belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PAXX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81 +14 more | View in SCUBA |
| Endothelial | SPP1 Inflammatory Activation Inflammation | ADAM15, ATG4A, C1orf54, C7orf50, C9orf40, CPXM2, EBF3, EIF2AK4 +9 more | View in SCUBA |
| Goblet cells | Pyroptosis Stress Response Stress | ADAM15, AURKAIP1, CDC37, CENPX, COMTD1, DDX39A, EEF1D, GSDMD +6 more | View in SCUBA |
| Innate lymphoid cells | Antigen Processing MHC-I Immune regulation | CMTM6, GUK1, IL2RB, IL4R, MYL12A, PSMA5, PSMB8, PSMB9 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytotoxic Lymphocyte Program cytotoxicity | ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB +9 more | |
| Natural Killer cells | Cytokine Feedback Response Immune regulation | DYNLL1, LMO4, N4BP2L2, PABPC1, PRPF4B, SOCS3, TPT1, VMP1 | View in SCUBA |
About the gene
| Synonyms | C9orf142, XLS |
|---|---|
| Chromosome | 9: 136992422-136993984 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | DNA damage, DNA repair |
Function
Non-essential DNA repair protein involved in DNA non- homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination. May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Involved in NHEJ by promoting the ligation of blunt-ended DNA ends. Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair. Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.