PABPC1 — Poly(A) binding protein cytoplasmic 1

PABPC1 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PABPC1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Immediate early activation TCR/AP1/NFKb pathway	ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more	View in SCUBA
CD8⁺ T cells	Ribosome Biogenesis RNA processing & translation	BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB +8 more	View in SCUBA
Endothelial	Wnt Angiogenic Remodeling ECM remodeling	ADAMTS4, ADGRL2, BAZ1A, FKBP11, IL4R, LDLRAD3, LEF1, MTHFD2 +5 more	View in SCUBA
Enterocytes	Nucleolar RNA-binding RNA processing & translation	HMGB1, HMGN2, HNRNPA1, HNRNPA2B1, HNRNPA3, HSP90AA1, HSP90AB1, NCL +2 more	View in SCUBA
Gamma-delta T cells	hnRNP Splicing Complex RNA processing & translation	ASXL1, DDX21, HNRNPA1, HNRNPC, HNRNPH3, HSPA9, NOP58, PAPOLA +5 more
Glial cells	DNA Damage Response Stress	BRD2, FAM53C, GADD45B, IER5, ING1, NFKBIZ, SRSF3, TUBB4B +1 more	View in SCUBA
Goblet cells	mRNA Translation Initiation RNA processing & translation	EEF1A1, EEF1B2, EIF3D, EIF3E, EIF3F, EIF3L, RACK1, SLC25A6 +2 more	View in SCUBA
Innate lymphoid cells	mRNA Stability & Splicing RNA processing & translation	BUD31, EIF4G2, GNAI3, HSPA9, PABPC4, PAIP2, PAPOLA, PRKAR1A +6 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more	View in SCUBA
Mucosal-associated invariant T cell	Housekeeping Translation Housekeeping	ARHGDIA, ARHGEF1, CCNI, DAZAP2, EEF2, HLA-A, HLA-B, HNRNPA1 +4 more
Natural Killer cells	Cytokine Feedback Response Immune regulation	DYNLL1, LMO4, N4BP2L2, PAXX, PRPF4B, SOCS3, TPT1, VMP1	View in SCUBA
Smooth muscle cells	Chaperonin heat-shock Stress	CYCS, DUSP1, HSPD1, HSPE1, ODC1, SLC25A25, SRSF3, UBE2D3	View in SCUBA

About the gene

Synonyms	PAB1, PABP1, PABPC2, PABPL1
Chromosome	8: 100685816-100722809
Predicted location	Intracellular
Essential gene	Yes
Protein class	Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	RNA-binding
Biological process	Host-virus interaction, mRNA processing, mRNA splicing, Nonsense-mediated mRNA decay

Function

Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability. (Microbial infection) Positively regulates the replication of dengue virus (DENV)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.