TUBB2A — Tubulin beta 2A class IIa
TUBB2A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TUBB2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Pol II Transcription Regulation DNA/chromatin regulation | ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more | |
| Glial cells | ENS Developmental TFs Development | ERBIN, FRMD3, HAND2, LRRC4C, MAP4K4, PYGL, SEC11C, SLC25A36 +2 more | View in SCUBA |
| Lymphatic endothelial | DNA Damage Response DNA/chromatin regulation | BRD2, BTG2, CITED2, H2AX, HBEGF, HEXIM1, INTS6, MAFB +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Stress-Induced Growth Arrest Stress | CDKN1A, GNA15, KDM6B, KLF10, MMP9, MYADM, NOCT, NR4A3 +8 more | |
| Natural Killer cells | Lymphocyte Trafficking Homing & TEM | BCL6, CTSD, LAPTM5, LITAF, ORAI1, P2RY8, PTPRJ, RNF166 +3 more | View in SCUBA |
| Smooth muscle cells | Microtubule biogenesis Cytoskeletal | ACOT7, FBXL22, ILF2, LIMS2, NUCB2, PGRMC1, PHGDH, PPP2R1A +3 more | View in SCUBA |
About the gene
| Synonyms | dJ40E16.7, TUBB, TUBB2 |
|---|---|
| Chromosome | 6: 3153497-3157544 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.