Basal metabolic housekeeping
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
A collection of ubiquitously expressed organelle/metabolic housekeeping genes: VDAC3 (mitochondrial porin), OSTC (oligosaccharyltransferase complex), AP2S1 (clathrin adaptor), IMPDH2 (nucleotide biosynthesis), GNG5, KIF5B (kinesin motor), GSTM3 and PRDX4 (redox detoxification), plus CNN2. No unifying pathological program; uniform expression across subsets and moderate coherence indicate a basal biosynthetic/metabolic housekeeping axis, likely co-varying with overall cell transcriptional output. It neighbors the tubulin/housekeeping module M13, consistent with a general 'cell-state activity' correlation rather than a specific program.
Genes
AP2S1, CNN2, GNG5, GSTM3, IMPDH2, KIF5B, OSTC, PRDX4, VDAC3
Most correlated modules
- mRNA Splicing Factors · correlation 0.82
- Microtubule biogenesis · correlation 0.80
- SMC focal adhesion · correlation 0.78
- Proliferative Biosynthesis · correlation 0.77
- ER Secretory Trafficking · correlation 0.77
- Mesenchymal Adhesion Program · correlation 0.76
- Proteasome And Translation · correlation 0.75
- Membrane Protein Turnover · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.