PRDX4 — Peroxiredoxin 4
PRDX4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRDX4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Nucleotide biosynthesis Housekeeping | CCT7, COPRS, DCTPP1, MRPL12, MRPL4, NHP2, NME1, PPA1 +6 more | View in SCUBA |
| Endothelial | NF-κB Oxidative Stress Stress | ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, COPRS +13 more | View in SCUBA |
| Fibroblasts | ER Protein Processing Vesicular traficking | ARPC2, ENO1, GTF3C6, KDELR2, LMAN1, OSTC, P4HB, PSMC4 +5 more | View in SCUBA |
| Goblet cells | Metabolic Stress Response Mitochondrial & OxPhos | ATP6V0B, C11orf24, CHCHD2, COX17, LDHA, MRPL52, SRA1, TAGLN2 +2 more | View in SCUBA |
| Macrophages | ER Protein Glycosylation Vesicular traficking | AK2, ALG3, ALG5, BABAM1, CKLF, CRELD2, DDOST, DPM3 +21 more | View in SCUBA |
| Monocytes | Biosynthetic Metabolic Activation Housekeeping | AHCY, EEF1B2, IMPDH2, NME1, NPM1, NUCKS1, PABPC4, PEBP1 +4 more | View in SCUBA |
| Smooth muscle cells | Basal metabolic housekeeping Housekeeping | AP2S1, CNN2, GNG5, GSTM3, IMPDH2, KIF5B, OSTC, VDAC3 | View in SCUBA |
About the gene
| Synonyms | AOE37-2 |
|---|---|
| Chromosome | X: 23664262-23686397 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins |
| Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.