SELENOK — Selenoprotein K
SELENOK belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SELENOK's module in each cell type
About the gene
| Synonyms | SELK |
|---|---|
| Chromosome | 3: 53884417-53891885 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress- induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.