SCUBA

TRIR — Telomerase RNA component interacting RNase

TRIR belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TRIR's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ANP32B, ATP5MC2, C19orf53, COX7C, EIF3H, EIF3M, EMC7, GPX4 +10 moreView in SCUBA
Gamma-delta T cellsT-bet Effector Differentiation
T cell maturation
ABHD17A, BCL7C, CAPNS1, CHST12, DGKZ, EFHD2, FMNL1, GNAI2 +15 more
Glial cellsMitochondrial Housekeeping
Mitochondrial & OxPhos
ATP5F1D, ATP6V1G1, COX7C, GNG5, RAN, SEM1, SH3BGRL3, ST3GAL4 +3 moreView in SCUBA
Goblet cellsSR Splicing Factors
RNA processing & translation
CLTA, GLRX5, MLEC, NDUFAB1, PPP1R14B, SRSF2, SRSF9, UQCRFS1 +1 moreView in SCUBA
Innate lymphoid cellsInnate Inflammatory Activation
Inflammation
ARL6IP5, BST2, CD2, CD63, FTL, HMGB1, ITM2B, MGST3 +7 moreView in SCUBA
MacrophagesProtein Biogenesis
Housekeeping
ATP6V0D1, B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46 +23 moreView in SCUBA
PericytesG-protein Signaling Scaffold
Housekeeping
BCAP29, FDPS, GNB1, GNB2, PPIA, RAC1, RAP1A, YWHAB +1 moreView in SCUBA
Smooth muscle cellsATP Synthase Complex
Mitochondrial & OxPhos
ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1E, ATP5MC1, ATP5MC2, ATP5MC3, ATP5ME +8 moreView in SCUBA

About the gene

SynonymsC19orf43, fSAP18, MGC2803, TERCIR
Chromosome19: 12730640-12734684
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding

Function

Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to cleave all four unpaired RNA nucleotides from the 5' end or 3' end with higher efficiency for purine bases

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.