SCUBA

TPX2 — TPX2 microtubule nucleation factor

TPX2 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TPX2's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsMitotic Spindle
Cell cycle		AURKB, CCNA2, CDCA3, CDCA8, CDK1, KIF2C, NDC80, NUF2 +3 moreView in SCUBA
CD8⁺ T cellsMitotic Spindle
Cell cycle		ASPM, BUB1, CENPA, CENPE, CENPF, DLGAP5, GTSE1, HMMR +6 moreView in SCUBA
EndothelialMitotic Spindle
Cell cycle		ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN +14 moreView in SCUBA
Gamma-delta T cellsMitosis Execution
Cell cycle		ASF1B, BUB1, CDCA8, CENPE, CENPF, CKS1B, EZH2, MAD2L1 +12 more
Goblet cellsMitotic Proliferation
Cell cycle		BIRC5, CCNA2, KIF20B, MKI67, PBK, RACGAP1, TOP2AView in SCUBA
Hematopoietic progenitor cellsMitotic Spindle
Cell cycle		BIRC5, CCNB2, CDC20, CDKN3, CEP55, DLGAP5, HMMR, MKI67 +1 more
MacrophagesMitotic Spindle
Cell cycle		ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1 +14 moreView in SCUBA
Natural Killer cellsMitotic Spindle
Cell cycle		ARL6IP1, ASPM, CENPF, CKS1B, KIF22, MKI67, NUSAP1, PTTG1 +3 moreView in SCUBA
Smooth muscle cellsMitotic Spindle
Cell cycle		AURKB, CCNA2, CDCA3, CDK1, KIF20A, MKI67, NUSAP1, PIMREG +4 moreView in SCUBA

About the gene

SynonymsC20orf1, C20orf2, DIL-2, FLS353, HCA519, p100
Chromosome20: 31739271-31801805
Predicted locationIntracellular
Essential geneYes
Protein classCancer-related genes, Essential proteins, Predicted intracellular proteins
Biological processApoptosis, Cell cycle, Cell division, Mitosis

Function

Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.