UBE2C — Ubiquitin conjugating enzyme E2 C
UBE2C belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G2/M Mitosis Cell cycle | AURKA, BUB1, CCDC34, CCNB1, CCNB2, CDC20, CDKN3, CENPA +7 more | View in SCUBA |
| CD8⁺ T cells | CDK1-Aurora Kinase Mitosis Cell cycle | AURKB, BIRC5, CCNA2, CDK1, CDKN3, CKS1B, KIF22, KIFC1 +2 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN +14 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Cell cycle | ASPM, CDCA8, GTSE1, KIF15, KIF2C, KIF4A, NCAPG, NUSAP1 +2 more | |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, AURKA, BIRC5, CCNA2, CCNB1, CCNB2, CDK1 +14 more | View in SCUBA |
| Natural Killer cells | Mitotic Spindle Cell cycle | ARL6IP1, ASPM, CENPF, CKS1B, KIF22, MKI67, NUSAP1, PTTG1 +3 more | View in SCUBA |
| Smooth muscle cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA3, CDK1, KIF20A, MKI67, NUSAP1, PIMREG +4 more | View in SCUBA |
About the gene
| Synonyms | UBCH10 |
|---|---|
| Chromosome | 20: 45812576-45816957 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Enzymes, Essential proteins, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.