TOP2A — DNA topoisomerase II alpha
TOP2A belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOP2A's module in each cell type
About the gene
| Synonyms | TOP2, TOP2alpha, TOPIIA |
|---|---|
| Chromosome | 17: 40388525-40417896 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Enzymes, Essential proteins, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Isomerase, Topoisomerase |
| Biological process | Biological rhythms |
Function
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.