MHC-I antigen presentation
Gene co-expression module in Smooth muscle cells
| Category | Inflammation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
Hubs are the MHC class I machinery (B2M, HLA-A, HLA-B, HLA-C) together with the interferon-inducible IFI27, indicating a baseline/tonic interferon-driven antigen-presentation program that smooth muscle cells readily express in inflamed or normal gut. The remaining genes (TMSB4X, S100A4, S100A6, VIM, TPPP3) reflect a synthetic/migratory, less-contractile SMC state that typically accompanies IFN-stimulated MHC-I upregulation, and NDUFA4 is a promiscuous high-expressor. Moderate coherence and weak membership of HLA-C/TPPP3 suggest a mixed MHC-I + modulated-phenotype module; its neighbors (contractile M16 and housekeeping M122) support reading this as the alternative, de-differentiated/immune-activated pole of SMC state rather than immune-cell contamination (no PTPRC, CD3, LYZ).
Genes
B2M, HLA-A, HLA-B, HLA-C, IFI27, NDUFA4, S100A4, S100A6, TMSB4X, TPPP3, VIM
Most correlated modules
- Rho GTPase Housekeeping · correlation 0.75
- OxPhos & proteasome · correlation 0.71
- SMC contractile apparatus · correlation 0.71
- Pericyte Notch Identity · correlation 0.68
- Non-muscle Actomyosin · correlation 0.68
- Sparse Mitoribosomal Housekeeping · correlation 0.63
- Ribonucleoprotein & translation · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.