Redox-Metabolic Housekeeping
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Moderately coherent, low-specificity module mixing ER translocon/glycosylation components (DAD1, SEC61B) with cytosolic detoxification and redox enzymes (COMT, GSTO1, POR) plus proteasome (PSMA5) and an OxPhos subunit (NDUFB5). No single dominant program; the hubs are broadly expressed metabolic/housekeeping genes, and its co-expression with the ER modules M64/M107 likely reflects shared overall biosynthetic/metabolic cell capacity rather than a discrete pathway.
Genes
COMT, DAD1, GSTO1, NDUFB5, POR, PREPL, PSMA5, SEC61B
Most correlated modules
- Endolysosomal Trafficking · correlation 0.78
- ER-Golgi Secretory Pathway · correlation 0.76
- Translocon & Proteostasis · correlation 0.73
- ER Secretory Trafficking · correlation 0.72
- ER Chaperone/UPR · correlation 0.70
- Activated Myofibroblast · correlation 0.68
- BMP-ID3 Matricellular · correlation 0.62
- ER-Golgi Secretory · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.