PHC2 — Polyhomeotic homolog 2
PHC2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Hypoxia Response Stress | ACSL4, AP2S1, ARFGAP3, C4orf48, EPAS1, HIF1A, IL4R, ISG20 +8 more | View in SCUBA |
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more | |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
| Monocytes | Autophagy Initiation Lysosomal & pahgocytosis | AAK1, AGFG1, ARID3B, FHIP2A, PTK2B, RIOK3, TMCO3, TRABD +1 more | View in SCUBA |
| Smooth muscle cells | ER-Golgi Secretory Pathway Protein processing & ER | BZW1, CCT3, COL15A1, GPC6, IFT57, KDELR2, LRPAP1, NFATC4 +4 more | View in SCUBA |
About the gene
| Synonyms | EDR2, HPH2 |
|---|---|
| Chromosome | 1: 33323623-33431095 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein, DNA-binding |
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.