XRN2 — 5'-3' exoribonuclease 2
XRN2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
XRN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ER Protein Folding Housekeeping | AHCYL1, CANX, CSNK1A1, HNRNPK, HSP90B1, JAK1, KDELR1, KTN1 +10 more | View in SCUBA |
| Goblet cells | RNA Decay Processing RNA processing & translation | CCNI, ILF2, RBPJ, RSL24D1, SRSF3, SYNCRIP, UBE2I, UBE2R2 +2 more | View in SCUBA |
| Innate lymphoid cells | Antigen Processing MHC-I Immune regulation | CMTM6, GUK1, IL2RB, IL4R, MYL12A, PAXX, PSMA5, PSMB8 +8 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E +18 more | View in SCUBA |
| Smooth muscle cells | ER-Golgi Secretory Pathway Protein processing & ER | BZW1, CCT3, COL15A1, GPC6, IFT57, KDELR2, LRPAP1, NFATC4 +4 more | View in SCUBA |
About the gene
| Chromosome | 20: 21303331-21389825 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Exonuclease, Hydrolase, Nuclease |
| Biological process | mRNA processing, Transcription, Transcription regulation, Transcription termination |
Function
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.