TENT5C — Terminal nucleotidyltransferase 5C

TENT5C belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TENT5C's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Hypoxia/metabolic stress Stress	ALG13, ARL4A, C9orf72, HIP1R, PDE4B, SC5D, SLC2A3, VPS37B +2 more	View in SCUBA
CD4⁺ T cells	Chemokine Migration migration & adhesion	CCR6, CYTIP, DDX24, FRMD4B, G3BP2, GNG2, GPBP1, KMT2E +7 more	View in SCUBA
Fibroblasts	Chromatin Transcriptional Regulation Developmental	BRD2, C6orf62, CBX4, GLS, KLHL15, LSMEM1, MKNK2, NUFIP2 +4 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3 +15 more
Goblet cells	mRNA Stability Control RNA processing & translation	BTG1, DNAJB6, PNRC1, SRSF5, TSC22D1, TUBA1A, TXNIP, UBXN1 +5 more	View in SCUBA
Innate lymphoid cells	mTOR Stress Response Stress	CEBPB, DDIT3, DDIT4, GLS, ID1, IFRD1, INTS6, JMJD6 +9 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Negative Feedback Immune regulation	ARL4A, BCAS2, CSRNP1, CXCR4, ENSG00000285976, IDS, ITPRIP, NFKBIA +7 more
Natural Killer cells	MAPK/AP-1 Signaling Inflammation	B3GNT7, BRAF, FAM177A1, FOSL2, GPBP1, PDE4B, PIK3R1, RALGAPA1 +4 more	View in SCUBA
Smooth muscle cells	Heat Shock Response Stress	C12orf65, CEMIP2, CHORDC1, DNAJA1, DNAJB1, FOSB, H2AFX, HSP90AA1 +8 more	View in SCUBA

About the gene

Synonyms	FAM46C, FLJ20202
Chromosome	1: 117606048-117628389
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Enzymes, Predicted intracellular proteins
Molecular function	Nucleotidyltransferase, RNA-binding, Transferase
Biological process	Host-virus interaction

Function

Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum- targeted protein. (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.