SLC20A1 — Solute carrier family 20 member 1
SLC20A1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC20A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more | View in SCUBA |
| Endothelial | Chronic Inflammatory Activation Inflammation | ABL2, ADAMTS9, DDX21, EMP1, FOSL2, HRH1, KRT10, LMNA +2 more | View in SCUBA |
| Fibroblasts | NF-κB Stress Response Inflammatory | EGR3, NAMPT, NCOA7, NFIL3, PHLDA1, PHLDA2, SAT1, SOD2 +3 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP +18 more | |
| Goblet cells | Heat Shock Response Stress | DNAJA1, EIF1AX, EIF5, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8 +5 more | View in SCUBA |
| Innate lymphoid cells | Dissociation Stress Response Stress | C12orf57, CA2, CALM2, EHD1, EIF4A2, IER2, MEPCE, NDRG1 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Activation Signaling TCR Signaling | AGAP2, ARHGAP45, CDK5RAP3, DNMT1, IL10RA, ITGAL, JADE2, NBR1 +6 more |
About the gene
| Synonyms | Glvr-1, GLVR1, PiT-1, PiT1 |
|---|---|
| Chromosome | 2: 112645939-112663825 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Host-virus interaction, Phosphate transport, Symport, Transport |
Function
Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Essential for cell proliferation but this function is independent of its phosphate transporter activity. (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.