GCLM — Glutamate-cysteine ligase modifier subunit
GCLM belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GCLM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ADA2, ANK3, CAMK4, CHD7, GNAO1, MPP7, NME4 +15 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Stress | CRK, DLC1, IFT20, KRAS, ODC1, SBDS, SERP1, SERPINH1 +7 more | View in SCUBA |
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | ATP1B3, F3, GRPEL1, HMOX1, PLIN2, SLC3A2, TXNRD1 | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
About the gene
| Synonyms | GLCLR |
|---|---|
| Chromosome | 1: 93885199-93909456 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Biological process | Glutathione biosynthesis |
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.