TNIP1 — TNFAIP3 interacting protein 1
TNIP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Complement Innate Immune Inflammation | C1R, C1S, CD47, CNDP2, COL5A2, CTSS, GRINA, GSDMD +9 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Cytoskeletal Metabolic Cytoskeleton & motility | ATP5F1B, ATXN10, CCT7, CD82, DNPH1, GADD45GIP1, HMGA1, MEA1 +14 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Inflammatory Activation Inflammation | ACHE, ANKLE2, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2 +9 more | View in SCUBA |
| Monocytes | NF-κB Signaling Inflammatory | BIRC3, ERN1, G0S2, ICAM1, IER3, IRAK2, NFKB1, PDE4B +4 more | View in SCUBA |
| Neutrophils | NF-κB Activation Inflammatory | EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLEK +6 more |
About the gene
| Synonyms | ABIN-1, KIAA0113, NAF1, VAN |
|---|---|
| Chromosome | 5: 151029945-151093577 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins |
| Biological process | Inflammatory response |
Function
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B- dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3- mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF- induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome- dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.