RNASET2 — Ribonuclease T2
RNASET2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNASET2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-I Antigen Presentation Anti-viral | B2M, BANK1, CD48, CYSLTR1, HLA-A, HLA-B, HLA-C, HLA-E +1 more | View in SCUBA |
| Innate lymphoid cells | cAMP-Glucocorticoid Suppression Immune regulation | CD7, CERK, CNDP2, COA1, NAP1L4, NEK7, NR3C1, PDE3B +3 more | View in SCUBA |
| Macrophages | Antimicrobial Oxidative Defense Antibacterial | ADAMDEC1, ALDOA, APOL3, CALHM6, CLEC10A, COX16, CPVL, DEFA5 +30 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Lysosomal & pahgocytosis | ABI3, CAMK1, CD300A, CHCHD10, DAPK1, FCGR3A, GNGT2, ICAM2 +5 more | View in SCUBA |
About the gene
| Synonyms | bA514O12.3, FLJ10907, RNASE6PL |
|---|---|
| Chromosome | 6: 166922113-166957191 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Endonuclease, Hydrolase, Lyase, Nuclease |
| Biological process | Immunity, Innate immunity |
Function
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.