PROX1 — Prospero homeobox 1
PROX1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PROX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Secretory progenitor Notch Epithelial development | ADAMTS14, ADCY5, ADGRG4, DOCK8, HEPACAM2, MEIS1, NBPF14, NBPF19 +5 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Specification endothelial development | ARHGAP29, BOD1L1, CALD1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8 +9 more | View in SCUBA |
About the gene
| Chromosome | 1: 213983181-214041510 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding, Repressor |
| Biological process | Biological rhythms, Transcription, Transcription regulation |
Function
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.