ATP6V0D1 — ATPase H+ transporting V0 subunit d1
ATP6V0D1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V0D1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative/ER stress Stress | ASAH1, B4GALT1, FAM210A, FOSL2, GEM, GZF1, HIC1, MAFG +6 more | View in SCUBA |
| Innate lymphoid cells | TRiC Chaperonin Folding Protein processing & ER | CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC, FAM162A +9 more | View in SCUBA |
| Macrophages | Protein Biogenesis Housekeeping | B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46, DNAJA2 +23 more | View in SCUBA |
About the gene
| Synonyms | ATP6D, ATP6DV, P39, VATX, Vma6, VPATPD |
|---|---|
| Chromosome | 16: 67438014-67481181 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport |
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.