ER Stress & UPR
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 26 genes have a known function matching the annotation |
Why this annotation
XBP1 (master UPR transcription factor), SDF2L1 (ER stress chaperone), SEC11C and SPCS3 (signal peptidase complex subunits, ER), DNAJC7 (HSP40 co-chaperone) define an ER stress/unfolded protein response program. PSMD4, PSMD7, PSMD8 (proteasome 19S regulatory subunits) support ERAD (ER-associated degradation). COPZ1 (COPI vesicle coat, ER-Golgi trafficking), ARL1 (Golgi ARF GTPase), PLP2 (proteolipid, ER membrane). Enrichment in inf_colono for SDF2L1, SEC11C, SPCS3 is consistent with increased secretory/ER stress in inflamed colonocytes. Neighbor M86 (vesicular trafficking) shares Golgi/membrane trafficking context.
Genes
Most correlated modules
- Proteasome Assembly · correlation 0.90
- Mitochondrial Ribosome · correlation 0.87
- Ubiquitin-Proteasome System · correlation 0.87
- Mitochondrial Maintenance · correlation 0.86
- Ribosome Biogenesis · correlation 0.78
- Vesicular Trafficking · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.